Otterbein received four goals each from Drew McDonald and Robby Fields, while Xander Seal finished with three goals and six assists.
Wooster started off with the lead thanks to a goal from Ted Wells off an assist from Peirce. However, Otterbein scored the next six goals to take a 6-1 lead after one period of play.
The Scots cut the deficit in the second quarter to trail at halftime 8-3. Kuhn scored twice in the period with his first goal assisted by Drake Nickolaison. Nickolaison himself scored later with 5:38 left in the half off an assist from David Fitzgerald.
Wells returned the assist to Peirce to start the third as Peirce scored in a man-up opportunity. Adam Yeo then got on the board with 32 seconds left in the third period.
Otterbein extended a 10-6 lead with three goals to kick off the fourth period. Kuhn and Peirce got on the board again and Otterbein finished the scoring with 1:19 left in the quarter.
Wesley Wagner made six saves for the Scots.
Connor Mangan recorded 13 of Wooster's 36 ground balls. Wooster succeeded in 14-of-18 clears and won 17-of-26 face offs. Wooster outshot the Cardinals 37-31.
Wooster drops to 0-2, while Otterbein moves to 2-1.
The Scots travel to John Carroll University on Sunday.